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Pregnant and breastfeeding individuals, those on anticoagulants or with bleeding disorders, and anyone with documented B12 toxicity (extremely rare) require provider consultation

This statement, published in the peer-reviewed Journal of Endocrinology and Metabolism, represents the consensus finding across all six trials and nearly 900 participants

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Baseline levels of serum copeptin, urinary hyaluronidase activity and AQP2/creatinine ratio were similar among groups and all decreased after water load, reaching their nadir at 120 min and then gradually recovering to baseline values

To date, nearly a decade of research has pointed to vitamin B12 as a safe, effective treatment of depression and anxiety